Description:
Human Cathepsin G (CG) is a serine protease, and a member of the peptidase S1 protein family, located in the azurophil granules of neutrophils. Studies have shown that CG when released from granulocytes binds to NK cells and augments NK cytotoxicity through its protease activity. CG has a specificity similar to that of Chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation.