Native Human Angiotensinogen

Synonyms:

Angiotensinogen, Serpin A8

Species:

Human

Cat. No.:

CSI14137B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

Please Inquire

Description:

Angiotensinogen (AGT) is a glycoprotein found in plasma at a concentration of 2.8-7.1 mg per 100mL in healthy individuals. AGT is produced primarily by the liver but also is synthesized in the brain, large arteries, kidneys and adipose tissue. In plasma it exists as a monomeric form (55-65 kDa) as well as a high molecular mass form (200-550 kDa). In non-pregnant individuals with normal blood pressure, the high molecular mass form accounts for 3% of total circulating AGT. In the first half of pregnancy the total AGT increases by 4-fold and the high molecular mass form increases by 20-fold. Up to 80% of the total AGT in amniotic fluid is the high molecular mass form. Angiotensinogen is an essential component of the renin-angiotensin system, a potent regulator of blood pressure, body fluid and electrolyte homeostasis. It functions as the substrate for human renin and is the precursor molecule for Angiotensins 1,2,3,4, 1-9, 1-7, 1-5 and 1-4. AGT is also a member of the SERPIN family but it is not known to possess protease-inhibitory activity. Levels in plasma are increased by plasma corticosteroid, estrogen, thyroid hormone and angiotensin-2 levels.

Entrez Symbol:

AGT

Uniprot Name:

Angiotensinogen

Uniprot ID:

P01019

Data PDF:

CSI14137

Source:

Human plasma

Molecular Weight:

55-56 kDa

Formulation:

Lyophilized from 30 mM Sodium Phosphate, pH 6.8

Purity:

>95% pure by SDS-PAGE.

Reconstitution:

Centrifuge vial prior to opening. Prepare the original volume with deionized water.

Storage/Stability:

Stable at 2-8°C for shipping. Store at -20°C to -80°C for up to 1 year.