Native Human Alpha-2-Macroglobulin, Fast Form

Molecule:

Alpha-2-Macroglobulin

Synonyms:

Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

Species:

Human

Cat. No.:

CRA116B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$300.00 BUY

Description:

Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a “trap” method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17–0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer’s disease and spongiform encephalopathies.

Entrez Symbol:

A2M

Uniprot Name:

Alpha-2-macroglobulin

Uniprot ID:

P01023

Data PDF:

CRA116x

Source:

Human plasma

Molecular Weight:

725 kDa, Homotetramer (180 MW subunit)

Formulation:

Lyophilized from 100 mM Sodium Phosphate, pH 7.2

Purity:

>95% pure by SDS-PAGE.

Reconstitution:

Centrifuge vial prior to opening. Prepare the original volume with deionized water.

Storage/Stability:

Stable at 2-8°C for shipping. Store at -80°C for up to 1 year.