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Native Human Alpha-1-Antitrypsin

Molecule:

alpha-1-antitrypsin/SERPINA1

Synonyms:

Alpha-1-Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1

Species:

Human

Cat. No.:

CSI19775B pdf (datasheet)

Quantity/Size:

5.0 mg

Price:

$480.00 BUY

Description:

Alpha 1-Antitrypsin (SERPINA1) is a glycoprotein serine protease inhibitor (serpin), inhibiting a wide variety of proteases. An acute-phase plasma protein found at 95-350 mg per 100 ml that functions as a protease inhibitor. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives.

Uniprot Name:

Alpha-1-Antitrypsin

Uniprot ID:

P01009

Data PDF:

CSI19775

Source:

Human plasma

Molecular Weight:

52 kDa

Formulation:

Lyophilized from 0.03 M Sodium Phosphate, 0.3 M NaCl, pH 6.5

Purity:

>95% by SDS-PAGE

Biological Activity:

75-100% inhibitory when tested with active-site titrated Porcine Pancreatic Trypsin using N-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.

Reconstitution:

Centrifuge vial prior to opening. Add deionized water to > 0.1 mg/ml.

Storage/Stability:

Store in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.