Native Human Alkaline Phosphatase, Liver, Partially Purified

Synonyms:

Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNS-ALP, TNSALP, Phosphocreatine phosphatase

Species:

Human

Cat. No.:

CSI10372B pdf (datasheet)

Quantity/Size:

100 U

Price:

$2,200.00 BUY

Description:

Native Human Alkaline Phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups in the 5- and 3- positions from many types of molecules, including nucleotides, proteins and alkaloids. In most mammals there are four different isozymes: placental (ALPP), germ cell (ALPG), intestinal (ALPI) and tissue non-specific (liver/bone/kidney) (ALPL/TNAP). In the Human, ALP is particularly concentrated in liver, bile duct, kidney, bone, (ALPL) and the placenta (ALPP). Elevated liver form is often due to liver pathologies, and likewise elevation of the bone form often indicates a bone pathology such as Paget’s disease. However, elevated ALP can be due to non-specific causes and does not always indicate serious disease. Nevertheless alkaline phosphatase is a very useful serum marker, with wide applications from diagnosing hepatoma to predicting mortality in dialysis patients.

Entrez Symbol:

ALPL

Uniprot Name:

Alkaline phosphatase, tissue-nonspecific isozyme

Uniprot ID:

P05186

Data PDF:

CSI10372

Source:

Human liver

Physical State:

Frozen liquid

Formulation:

10mM TRIS, 1mM MgCl2, 5um MnCl2, 5uM ZnCl2 and 50uM P-5-P, 0.09% NaN3

Purity:

Partially purified

Biological Activity:

49.1 IU/mL @ 37°C by Roche, Cobas c501

Storage/Stability:

Store at -80°C for up to 1 year.