Native Bovine Cathepsin D, Spleen

Synonyms:

Cathepsin D

Species:

Bovine

Cat. No.:

CNC005A pdf (datasheet)

Quantity/Size:

1000 Units

Price:

$850.00 BUY

Description:

Cathepsin D is an endosomal-lysosomal aspartic protease produced as an inactive enzyme, called a preproenzyme, with extra protein segments attached. These segments must be removed, followed by additional processing steps, for the enzyme to become active. The mature, active cathepsin D enzyme is made up of two parts, one light chain and one heavy chain. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Uniprot Name:

Cathepsin D

Uniprot ID:

P80209

Data PDF:

CNC005

Source:

Bovine spleen

Formulation:

Lyophilized from 2 mM Sodium phosphate, pH 6.5

Purity:

≥ 95% by SDS-PAGE

Biological Activity:

> 400 Units/mg
One unit is defined as the amount of enzyme which digests hemoglobin. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37ºC. Measured as TCAsoluble product using acid-denatured hemoglobin (0.2% in reaction mixture) as the substrate in 0.1 M formate, pH 3.3.

Specific Activity:

> 400 Units/mg
One unit is defined as the amount of enzyme which digests hemoglobin. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37ºC. Measured as TCAsoluble product using acid-denatured hemoglobin (0.2% in reaction

Storage/Stability:

Store at -80°C up to 1 year