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Mouse Anti-Mouse VEGF (Clone MAB0705) Neutralizing mAb

Synonyms:

Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF

Cat. No.:

CMV122 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$1,290.00 BUY

Description:

This antibody is a mouse monoclonal antibody that binds specifically to VEGF, and it can neutralize the bioactivity of VEGF.

Vascular Endothelial Growth Factor A (VEGFA) is a member of the PDGF/VEGF growth factor family and is often found as a disulfide linked homodimer. VEGFA is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of VEGFA is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in VEGFA have been associated with proliferative and non-proliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Uniprot Name:

Vascular endothelial growth factor A

Uniprot ID:

Mouse Q00731
Human P15692

Data PDF:

CMV122

Purity:

> 95% by SDS-PAGE

Specificity:

Recognizes Mouse and Human VEGFA

Host Species:

Mouse

Immunogen:

Recombinant mouse VEGF, corresponding to a region within amino acids 27 and 190.

Isotype:

IgG1

Clone:

MAB0705

Formulation:

Lyophilized from sterile filtered solution in PBS

Purification:

Protein G affinity chromatography

Reconstitution:

Reconstitute with 500 ml sterile PBS to a final concentration of 200 mg/ml.

Application:

Neutralizing , WB

Storage/Stability:

Store lyophilized antibody for at least 1 year at -20o C to -80o C.