Vitronectin

Vitronectin, VN, S-protein, Serum-spreading factor, V75

Human

MON3050 pdf (datasheet)

1 ml

$1,120.00 BUY

0.1 mg/ml

Vitronectin is an abundant glycoprotein (~75 kDa), consisting of 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates. Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctional protein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by the complement C5b-9 complex, and it modulates antithrombin III thrombin action in blood coagulation. The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domain with hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexin homology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and is responsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with the urokinase plasminogen activator receptor (uPAR). Vitronectin uPAR interaction is required and sufficient to initiate downstream changes in cell morphology, migration and signal transduction. MON3050 binds to soluble vitronectin as well as to membrane bound vitronectin.

VTN

Vitronectin

P04004

MON3050

Human Vitronectin

Mouse

IgG1

BV1

PBS containing 0.1% BSA and 0.02% sodium azide

ELISA, FC, IF, IP , WB

typical starting dilution 1:50

Store at 2-8°C for up to 1 year.