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Mouse Anti-Human TSHR / LGR3 (M22) mAb

Synonyms:

Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, M22

Species:

Human

Cat. No.:

FHD18150A pdf (datasheet)

Quantity/Size:

50 ug

Price:

$255.00 BUY

Concentration:

1.0 mg/ml, lot specific

Description:

TSH receptor (TSHR) autoantibody (TRAb) is the serological hallmark of Graves’ disease. M22 is a mouse mAb version of the autoantibody to TSHR prepared using lymphocytes from a patient with Graves' disease. It has powerful thyroid stimulating and TSH binding inhibiting activity and binds to the TSHR with high affinity. The hyperthyroidism of Graves’ disease is caused by TRAbs with stimulating (agonist) activity.

Entrez Symbol:

TSHR

Uniprot Name:

Human thyrotropin receptor

Uniprot ID:

P16473

Data PDF:

FHD18150

Purity:

> 95% as determined by SDS-PAGE

Specificity:

Human thyrotropin receptor

Host Species:

Mouse

Isotype:

IgG2a

Clone:

M22

Formulation:

0.01M PBS buffer, pH 7.4

Purification:

Protein A/G affinity chromatography

Application:

ELISA, FC

Storage/Stability:

Store at -20°C to -80°C for up to 1 year