• Home /
  • Mouse Anti-Human TIM-3 (Clone B-K48) mAb

Mouse Anti-Human TIM-3 (Clone B-K48) mAb

Synonyms:

T-cell immunoglobulin mucin receptor 3, Hepatitis A virus cellular receptor 2, HAVcr-2, CD366, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3

Species:

Human

Cat. No.:

CDM563 pdf (datasheet)

Quantity/Size:

200 tests

Price:

$320.00 BUY

Description:

TIM-3, a negative regulatory immune checkpoint, is detected in different types of immune cells, including T cells, regulatory T cells (Tregs), dendritic cells (DCs), B cells, macrophages, nature killer (NK) cells, and mast cells. TIM-3 is a type I membrane protein (281 aa) with four ligands, including galectin-9 (Gal-9), carcinoembryonic antigen cell adhesion molecule 1 (CEACAM-1), high-mobility group protein B1 (HMGB1), and phosphatidylserine (PS). Recent studies have highlighted that TIM-3 has an important role to play in T-cell exhaustion and correlates with the outcome of anti-PD-1 therapy. Targeting TIM-3 might be a promising approach for cancer immunotherapy.

Entrez Symbol:

HAVCR2

Uniprot Name:

T-cell immunoglobulin mucin receptor 3

Uniprot ID:

Q8TDQ0

Data PDF:

CDM563

Specificity:

Recognizes native and recombinant hTIM-3, both soluble and membrane forms.

Host Species:

Mouse

Immunogen:

Recombinant human TIM-3/Fc

Isotype:

IgG1 Kappa light chain

Clone:

B-K48

Formulation:

Sterile-filtered PBS, 1% BSA, 0.09% sodium azide

Application:

FC

Application notes:

Flow cytometry: Use 10 μl to label 10e6 cells or 100 μl of whole blood

Storage/Stability:

Store at 2-8°C.