Mouse Anti-Human Phospho-Tau (pS396/pS404) (PHF1) mAb

Synonyms:

Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau

Species:

Human

Cat. No.:

RHC82421A pdf (datasheet)

Quantity/Size:

100 µg

Price:

$475.00 BUY

Concentration:

1.0 mg/ml, lot specific

Description:

Tau protein is a microtubule-associated protein, predominantly expressed in the neurons, closely associated with the proper functioning of the cytoskeletal network in terms of microtubule assembly. Tau protein in the CSF is considered as an important biomarker of several disorders of the CNS where axonal damage is contemplated.

In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). Phospho-tau PHF-1 is a monoclonal antibody that recognizes phosphorylated tau proteins in the brains of people with Alzheimer's disease and other tauopathies. It's used to assess the progression of tau pathology and to study potential treatments.

Entrez Symbol:

MAPT

Uniprot Name:

Microtubule-associated protein tau

Uniprot ID:

P10636

Data PDF:

RHC82421

Purity:

> 95% by SDS-PAGE and SEC-HPLC

Specificity:

Human (phosphorylated at S396 and S404) Microtubule-associated protein tau

Host Species:

Mouse

Isotype:

IgG2a kappa light chain

Clone:

PHF1

Formulation:

0.01M PBS, pH 7.4

Purification:

Protein A/G affinity chromatography from cell culture supernatant

Application:

ELISA

Storage/Stability:

Recommended storage, undiluted at 2-8°C for up to 1 week, or in working aliquots at -20°C to -80°C for up to 1 year. Avoid freeze/thaw cycles.