NF

Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein

Human

MON3011 pdf (datasheet)

100 µg

$830.00 BUY

1 mg/ml

MON 3011 recognizes a phosphorylated epitope on heavy neurofilament protein (210 kDa) of various species. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons and are biochemically very stable. Neurofilaments (NFs) are a type of intermediate filaments (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights – neurofilament heavy protein (NF-H), medium (NF-M) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm.

NEFH

Neurofilament heavy polypeptide

P12036

MON3011

Human Neurofilament heavy protein

Mouse

Pellet of porcine brain cold-stable proteins after depolymerization of microtubules

IgG1

NF-01

Purified antibody in PBS containing 15mM sodium azide

ICC, IHC, WB

Store at 2-8°C for up to 1 year.