CD20

B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1

Human

MON1111 pdf (datasheet)

100 µg

$700.00 BUY

1 mg/ml

MON1111 recognizes CD20, a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and Bcell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface.

MS4A1

B-lymphocyte antigen CD20

P11836

MON1111

CD20

Mouse

Raji human Burkitt's lymphoma cell line

IgG1

MEM-97

Liquid. PBS, pH 7.4 containing 15 mM sodium azide

FC, IP

Stable for at least one year at 2-8°C.