MMP7

Matrilysin, Matrin, Matrix metalloproteinase -7, Pump-1 protease, Uterine metalloproteinase

Human

CMM116 pdf (datasheet)

100 μg

$800.00 BUY

Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of the extracellular matrix including collagen IV and X, gelatin, casein, laminin, aggrecan, entactin, elastin and versican. MMP-7 is implicated in the activation of other proteinases such as plasminogen, MMP-1, MMP-2, and MMP-9. In addition to its roles in connective tissue remodeling and cancer, MMP-7 also regulates intestinal α-defensin activation in innate host defense, releases tumor necrosis factorα in a model of herniated disc resorption, and cleaves FasL to generate a soluble form in a model of prostate involution. Structurally, MMP-7 is the smallest of the MMPs and consists of two domains: a prodomain that is cleaved upon activation and a catalytic domain containing the zincbinding site.

Matrilysin

P09237

CMM116

Recognizes human MMP-7

Mouse

Recombinant human MMP-7

IgG2

4C21

Lyophilized from sterile filtered PBS

Protein G affinity chromatography

Centrifuge vial briefly prior to opening. Add 500 µl sterile PBS to the vial for a concentration of 200 µg/ml. Gently mix, allow a few minutes to solubilize completely. Do not vortex.

Western Blot: suggested dilution 1:500-1:2000
IHC-P: suggested dilution 1:50-1:200

Lyophilized antibody is stable for at least 1 year from date of receipt at -20°C to -80°C. Reconstituted antibody may be prepared as aliquots and stored at -20°C to -80°C for at least six months. Avoid repeated freeze-thaw cycles.