• Home /
  • Mouse Anti-Human CD29 (Clone MEM-101A) mAb

Mouse Anti-Human CD29 (Clone MEM-101A) mAb

Synonyms:

Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29

Species:

Human

Cat. No.:

MON1075 pdf (datasheet)

Quantity/Size:

100 µg

Price:

$700.00 BUY

Concentration:

1 mg/ml

Description:

MON1075 reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1- alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumor cells during selection in presence of antitumor drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation.

Entrez Symbol:

ITGB1

Uniprot Name:

Integrin beta-1

Uniprot ID:

P05556

Data PDF:

MON1075

Specificity:

Human CD29

Host Species:

Mouse

Immunogen:

Raji Burkitt's lymphoma cell line

Isotype:

IgG1

Clone:

MEM-101A

Formulation:

Liquid. PBS, pH 7.4 containing 15 mM sodium azide

Application:

FC, IP

Storage/Stability:

Stable for at least one year at 2-8°C.