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  • Mouse Anti-Human Integrin beta-1 / CD29 (Clone BV7) mAb

Mouse Anti-Human Integrin beta-1 / CD29 (Clone BV7) mAb

Molecule:

Integrin beta 1/CD29

Synonyms:

Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29

Species:

Human

Cat. No.:

MON2031 pdf (datasheet)

Quantity/Size:

1 ml

Price:

$1,220.00 BUY

Concentration:

0.1 mg/ml

Description:

Integrin beta-1 is a ubiquitously expressed ~89 kDa type I transmembrane protein functioning as receptor when heterodimerized with one alpha subunit. It belongs to the integrin beta chain family consisting of four different genes, encoding multiple βintegrins via alternative splicing. Ligand-recognition depends on the composition of the heterodimer: either collagen, fibronectin, VCAM1, laminin, cytotactin, osteopontin, epiligrin, thrombospondin and CSPG4 can bind to the integrin-complex. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro).

Entrez Symbol:

ITGB1

Uniprot Name:

Integrin beta-1

Uniprot ID:

P05556

Data PDF:

MON2031

Specificity:

Human Integrin beta-1 Does not recognize α5β1 complex and not the cytoplasmic part of the β1-subunit.

Host Species:

Mouse

Immunogen:

Human umbilical vein EC

Isotype:

IgG1

Clone:

BV7

Formulation:

Purified antibody in PBS containing 0.1% BSA

Application:

FC, IHC, IP , WB

Application notes:

BV7 binds to several tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC-1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells.

Storage/Stability:

Store at 2-8°C for up to 1 year.