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Mouse Anti-Human Integrin alpha-V/beta-3 (Clone BV3) mAb

Synonyms:

Integrin alpha-V / Integrin beta-3

Species:

Human

Cat. No.:

MON2032 pdf (datasheet)

Quantity/Size:

1 ml

Price:

$1,120.00 BUY

Concentration:

0.1 mg/ml

Description:

MON 2032 reacts with human alpha-V/beta-3 integrin present on human endothelium cells. In cell matrix adhesions, clustered integrins (each made up of a noncovalently linked alpha and beta subunit) bind to endothelium cell matrix (ECM) components via their globular head domains. They connect to the actin cytoskeleton via adaptor proteins that bind their short cytoplasmic tails. Cell matrix adhesions also act as signalling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin mediated adhesion regulates the actions of RhoGTPases, which in turn affect cell-cell adhesion. The converse process can also take place: the activity of Rho-GTPases can be modulated by cadherins in adherens junctions. Besides mediating adhesion to ECM components, integrins participate in the assembly of an ECM. Alpha-V/beta-3 integrin is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectinand von Willebrand factor.

Entrez Symbol:

ITGAV: ITGB3

Uniprot Name:

Integrin alpha-V / Integrin beta-3

Uniprot ID:

P06756, P05106

Data PDF:

MON2032

Host Species:

Mouse

Isotype:

IgG1

Clone:

BV3

Formulation:

Purified antibody solution in PBS containing 0.1% BSA and 0.02% sodium azide.

Application:

ELISA, FC, IF, IHC-P, IP

Application notes:

Starting dilution 1:50

Storage/Stability:

The undiluted antibody should be stored at 2-8°C until expiration date.