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  • Mouse Anti-Human IL-28A / IFN-lambda-2 (Clone B-Z28) mAb, Azide Free

Mouse Anti-Human IL-28A / IFN-lambda-2 (Clone B-Z28) mAb, Azide Free

Molecule:

CXCL11

Synonyms:

Interferon lambda-2, IFN-lambda-2, Cytokine Zcyto20, Interleukin-28A, IL-28A

Species:

Human

Cat. No.:

CDM516B pdf (datasheet)

Quantity/Size:

500 ug

Price:

$650.00 BUY

Concentration:

1.0 mg/ml

Description:

Interleukin-28A is a type III interferon that is upregulated in response to viral infection. It acts primarily on epithelial cells through a receptor complex that contains IL-10 R beta and IL-28 R alpha/IFN-lambda R1. IL-28A promotes the Th1 polarization of dendritic cells in the airway (e.g. production of IL-12 p70 and IFN-gamma) and inhibits Th2 and Th17 mediated inflammation. In the liver, however, the IL-28A induced Th1 cytokine response contributes to inflammation in T cell mediated hepatitis. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses. In contrast, it is upregulated in invasive bladder cancer where it promotes tumor cell migration.

Entrez Symbol:

IFNL2

Uniprot Name:

Interferon lambda-2

Uniprot ID:

Q8IZJ0

Data PDF:

CDM516

Specificity:

Recognizes native and recombinant human IL-28A

Host Species:

Mouse

Immunogen:

Recombinant human IL-28A

Isotype:

IgG2a kappa light chain

Clone:

B-Z28

Formulation:

Sterile-filtered PBS. Carrier and preservative free.

Application:

ELISA

Storage/Stability:

Store at 2-8°C.