Type II interleukin-1 receptor antagonist

Human

MON5080 pdf (datasheet)

100 µg

$1,120.00 BUY

0.1 mg/ml

This monoclonal antibody reacts specifically with human IL-1ra3. The IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1α and IL-1β), converting enzymes, antagonistic two receptors (IL-1 R1 and IL-1 RII) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-ra2) and icIL-1 ra type II (IL-ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is no limit the pro-inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.

IL-1ra3

MON5080

Human Interleukin-1ra3

Mouse

IgG1

2D11

PBS containing 0.1% BSA, 0.02% sodium azide

ELISA, IHC-F, WB

Store at 2-8°C for up to 1 year.