IL-1R-2, L-1RT-2, L-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b

Human

MON5084 pdf (datasheet)

100 µg

$1,120.00 BUY

0.1 mg/ml

This monoclonal antibody reacts specifically with human IL-1 RII. The IL-1 system includes two agonists (IL-1α and IL-1β), converting enzymes, antagonistic, two receptors (IL-1 R1 and IL-1 RII) and the IL-1 receptor accessory protein. The IL-1 RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signaling IL-1 RI. The decoy IL-1 RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by co-receptor competition. Further a soluble form of IL-1 RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes polymorphonuclear cells, B cells and fibroblasts.

IL1R2

IL-1R-2

P27930

MON5084

Human IL-1 Receptor Type 2

Mouse

IgG2a

6G5

PBS containing 0.02% sodium azide and 0.1% bovine serum albumin.

ELISA

Store at 2-8°C for up to one year.