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Mouse Anti-Human IL-12 p35 + p70 (Clone B-T21) mAb

Molecule:

IL-12

Synonyms:

Interleukin-12 subunit alpha, IL-12A, IL-12 p35, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, NK cell stimulatory factor chain 1, NKSF1

Species:

Human

Cat. No.:

CDM271C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

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Concentration:

1 mg/ml

Description:

IL-12p70 is the biologically active form and is composed of two subunits: IL-12p35 (also named IL-12A) and IL-12p40 (also named IL-12B). The p35 subunit has homology to IL-6, while p40 has homology with IL-23. The p40 subunit has been found to be expressed in a higher excess over p70. It is present in serum and plasma as a monomer, a heterodimer with IL-12p35 (biologically active IL-12p70) or heterodimer with IL-23p19 (IL-23). The subunits are genetically unrelated and regulated independently: IL-12p40 is produced constitutively and in excess of IL-12p35 and IL-23p19.

Entrez Symbol:

IL12A

Uniprot Name:

Interleukin-12 subunit alpha

Uniprot ID:

P29459

Data PDF:

CDM271

Specificity:

Recognizes native and recombinant human IL-12, the p35 subunit and p70 heterodimer

Host Species:

Mouse

Immunogen:

Recombinant Human IL-12

Isotype:

IgG1 Kappa light chain

Clone:

B-T21

Formulation:

Sterile filtered PBS, carrier and preservative free.

Application:

ELISA, FS

Application notes:

Functional Studies: Inhibits IL-12 induced IFN-gamma synthesis on PHA-activated lymphocytes.

ELISA: Use as a Capture Ab at 0.3-1 µg/ml in a human IL-12 sandwich Immunoassay to detect human IL-12 in combination with biotinylated human IL-12 p70 Detection Antibody (Cat No CDM429).

Storage/Stability:

Stable at 2-8°C for 1 year. For longer storage, freeze in aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.