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Mouse Anti-Human CD64 (Clone B-T44) mAb

Synonyms:

High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, Fc-gamma RIA, FcgammaRIa, CD64

Species:

Human

Cat. No.:

CDM555 pdf (datasheet)

Quantity/Size:

200 tests

Price:

$320.00 BUY

Description:

High affinity immunoglobulin gamma Fc receptor I (CD64) is an integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines such as IFNγ and G-CSF can induce CD64 expression on these cells.

Entrez Symbol:

FCGR1A

Uniprot Name:

High affinity immunoglobulin gamma Fc receptor I

Uniprot ID:

P12314

Data PDF:

CDM555

Specificity:

Recognizes both native and recombinant CD64

Host Species:

Mouse

Immunogen:

Recombinant human CD64

Isotype:

IgG2b Kappa light chain

Clone:

B-T44

Formulation:

Sterile-filtered PBS, 1% BSA, 0.09% sodium azide

Application:

FC

Application notes:

Flow cytometry: Use 10 μl to label 10e6 cells or 100 μl of whole blood

Storage/Stability:

Store at 2-8°C.