• Home /
  • Mouse Anti-Human CD46 (Clone MEM-258) mAb

Mouse Anti-Human CD46 (Clone MEM-258) mAb

Synonyms:

Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46

Species:

Human

Cat. No.:

MON2000 pdf (datasheet)

Quantity/Size:

100 µg

Price:

$750.00 BUY

Concentration:

0.5 mg/ml

Description:

MON 2000 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome.

Entrez Symbol:

CD46

Uniprot Name:

Membrane cofactor protein

Uniprot ID:

P15529

Data PDF:

MON2000

Specificity:

Human CD46

Host Species:

Mouse

Immunogen:

HPB-ALL human T cell line

Isotype:

IgG1

Clone:

MEM-258

Formulation:

PBS containing 0.1% sodium azide

Application:

FC, IP , WB

Storage/Stability:

Store as supplied for up to 1 year at 2-8°C.