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Mouse Anti-Human CD22 (Clone MEM-01) mAb

Synonyms:

B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14

Species:

Human

Cat. No.:

MON1067 pdf (datasheet)

Quantity/Size:

100 µg

Price:

$700.00 BUY

Description:

MON1067 reacts with CD22, a 130 kDa type Itransmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a threshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Uniprot ID:

P20273

Data PDF:

MON1067

Specificity:

Human and non-human primate CD22/B-cells

Host Species:

Mouse

Immunogen:

Raji Burkitt's lymphoma cell line

Isotype:

IgG1

Clone:

MEM-01

Formulation:

Liquid. PBS, pH 7.4 containing 15 mM sodium azide

Application:

FC, IP , WB

Storage/Stability:

Store as supplied for up to 1 year at 2-8°C.