Lewis X, Le(x) stage-specific embryonic antigen-1, SSEA-1, 3- fucosyl-N-acetyl-lactosamine

Human

MON1182 pdf (datasheet)

100 µg

$700.00 BUY

1 mg/ml

CD15 (Lewis X, Le(x) stage-specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3- fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumor cells, expressed on virtually all peripheral blood granulocytes. The CD15 antigen is expressed on approximately 95% of human peripheral blood eosinophils and neutrophils and is present on approximately 20% of mature circulating monocytes. Anti-CD15 has virtually no reactivity with T or B cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin and acute disease.

Lewis X

MON1182

Mouse

Human granulocytes

IgM

MEM-158

Tris-buffered saline (TBS) containing 15 mM sodium azide

FC, IP

Store as supplied for up to 1 year at 2-8°C.