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Mouse Anti-Human CD11b / CR3 (Clone Bear-1) mAb

Molecule:

CD11b | CR3

Synonyms:

CD11 antigen-like family member B, Integrin alpha-M, CR-3 alpha chain

Species:

Human

Cat. No.:

MON1019-1 pdf (datasheet)

Quantity/Size:

1 ml

Price:

$480.00 BUY

Concentration:

100 μg/ml

Description:

Mouse Anti-Human CD11b/CR3 Clone Bear-1 recognizes CD11b an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation.

CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, Tcells, B-cells and dendritic cells. After activation, the expression is upregulated.

Entrez Symbol:

ITGAM

Uniprot Name:

Intergrin alpha-M

Uniprot ID:

P11215

Data PDF:

MON1019

Specificity:

The antibody reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer present on human NK-cells, monocytes and granulocytes.

Host Species:

Mouse

Isotype:

IgG1

Clone:

Bear-1

Formulation:

Sterile filtered solution in PBS, 0.02% Sodium Azide, 0.1% BSA.

Purification:

Protein G affinity chromatography

Application:

FC, IHC-F, IP

Application notes:

For IHC-F and flow cytometry, dilutions to be used depend on detection system applied. The typical starting working dilution is 1:10. It is recommended that users test the reagent and determine their own optimal dilutions.

Storage/Stability:

Store antibody at 2-8°C