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This antibody is highly specific for human C-peptide of human proinsulin. No cross reactions were found with other serum proteins.
Proinsulin is made up of 86 residues in humans and formed by three distinct chains. The A chain, B chain, and the area connecting the two named the C peptide. The correct structure of proinsulin is crucial for the correct folding of mature insulin, as the placement of the C peptide sets the molecule up to create correctly positioned disulfide bonds in and between the A and B chains.