Prothrombin (Factor II) is a single-chain vitamin K-dependent 579 amino acid glycoprotein zymogen. Prothrombin is proteolytically activated to thrombin by the prothrombinase enzyme complex in the coagulation cascade common pathway. The serine protease thrombin converts plasma fibrinogen to insoluble fibrin. Prothrombin levels are decreased by anticoagulant therapy, vitamin K deficiency and severe liver disease. Prothrombin (Factor II) is a single-chain vitamin K-dependent 579 amino acid glycoprotein zymogen. Prothrombin is proteolytically activated to thrombin by the prothrombinase enzyme complex in the coagulation cascade common pathway. The serine protease thrombin converts plasma fibrinogen to insoluble fibrin. Prothrombin levels are decreased by anticoagulant therapy, vitamin K deficiency and severe liver disease.

Specificity:       Total Human Prothrombin

Sensitivity:        0.078 ng/ml

Range:               0.25-100 ng/ml

Sample Type:   Plasma and serum