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Human Anti-SARS-CoV-2 (2019-nCoV) Spike-RBD Tixagevimab (AZD8895) Neutralizing mAb

Synonyms:

Spike glycoprotein, S glycoprotein receptor binding domain, S-RBD AZD8895, Tixagevimab, COV2-2196

Species:

SARS-CoV-2

Cat. No.:

CPC537B pdf (datasheet)

Quantity/Size:

100 µg

Price:

Please Inquire

Concentration:

1.0 mg/ml, lot specific

Description:

New catalog number DVV00308

Tixagevimab (AZD8895 or COV2-2196) was derived from B-cells donated by convalescent patients after SARS-CoV-2 viral infection. AZD8895 is able to block the binding of the SARS-CoV-2 virus to host cells and protect against infection in cell and animal models of disease.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). Spike glycoprotein is cleaved into the following 3 chains, Spike protein S1, Spike protein S2, Spike protein S2'. Spike protein S1 attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Spike glycoprotein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests.

Uniprot Name:

Spike glycoprotein

Uniprot ID:

P0DTC2

Data PDF:

CPC537

Purity:

> 95% by reducing and non-reducing SDS-PAGE

Specificity:

Recognizes SARS-CoV-2 Spike-RBD protein

Host Species:

Human

Immunogen:

Derived from B-cells donated by convalescent patients after SARS-CoV-2 viral infection

Isotype:

IgG

Clone:

AZD8895 (Tixagevimab ) or COV2-2196

Formulation:

Sterile-filtered PBS, pH 7.5 preservative free.

Purification:

Protein A affinity chromatography

Application:

ELISA, FS , Neutralizing , WB

Storage/Stability:

Stable at 2-8°C for 1 week or for up to 1 year at -20°C to -80°C. It is recommended to prepare single-use aliquots of undiluted product and store -20°C to -80°C.