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Human Anti-SARS-CoV-2 Spike-RBD Bebtelovimab (LY-CoV1404 / LY3853113) Neutralizing mAb

Synonyms:

Spike glycoprotein, Spike receptor binding domain, Spike-RB protein, Bebtelovimab, LY-CoV1404, LY3853113

Species:

SARS-CoV-2

Cat. No.:

CPC539A pdf (datasheet)

Quantity/Size:

50 µg

Price:

Please Inquire

Concentration:

1.0 mg/ml, lot specific

Description:

New catalog number DVV00319

LY-CoV1404 (LY3853113) is a fully human anti-SARS-CoV-2 monoclonal antibody selected based on its potential to neutralize the virus in vitro, kill infected cells, provide a high barrier to resistance, and achieve high concentrations in the lungs (one of the major sites of infection). Derived from plasma of a convalescent patient with Covid-19, LY-CoV1404 potently neutralizes SARS-CoV-2 authentic virus and all known variants of concern including the B.1.617.2 (Delta) variant and variants of Omicron. Binding epitope on RBD of SARS-CoV-2 is rarely mutated. Bebtelovimab was selected for clinical development based on its potential to both block viral entry into healthy cells and clear infected cells.

Entrez Symbol:

S

Uniprot Name:

Spike glycoprotein

Uniprot ID:

P0DTC2

Data PDF:

CPC539

Purity:

> 95% by reducing and non-reducing SDS-PAGE

Specificity:

Recognizes SARS-CoV-2 Spike-RBD. The RBD positions comprising the LY-CoV1404 epitope are highly conserved.

Host Species:

Human

Isotype:

IgG1 Kappa light chain

Clone:

LY-CoV1404 / LY3853113 (Bebtelovimab)

Formulation:

Sterile-filtered PBS, pH 7.5 preservative free.

Purification:

Protein A affinity chromatography

Application:

ELISA, FS , Neutralizing , WB

Storage/Stability:

Stable at 2-8°C for 1 week or for up to 1 year at -20°C to -80°C. It is recommended to prepare single-use aliquots of undiluted product and store -20°C to -80°C.