Human Anti-SARS-CoV-2 (2019-nCoV) Spike Glycoprotein Sotrovimab (VIR-7831 / GSK4182136) Neutralizing mAb

Synonyms:

Spike glycoprotein, Spike receptor binding domain, Spike-RB protein, VIR-7831, GSK4182136, Sotrovimab

Species:

SARS-CoV-2

Cat. No.:

CPC538B pdf (datasheet)

Quantity/Size:

100 µg

Price:

Please Inquire

Concentration:

1.0 mg/ml, lot specific

Description:

New catalog number DVV00307

VIR-7831 (GSK4182136) is a fully human anti-SARS-CoV-2 monoclonal antibody selected based on its potential to neutralize the virus in vitro, kill infected cells, provide a high barrier to resistance, and achieve high concentrations in the lungs (one of the major sites of infection). . Sotrovimab was derived from a parent antibody (S309), first isolated in 2003 from an individual's memory B cells who had recovered from a SARS-1 coronavirus infection. Sotrovimab differs from S309 in a particular way. It is purposefully engineered to possess two mutations in the Fc region. These are M428L and N434S, colloquially referred to as the LS mutation. These two mutations confer enhanced antibody binding to the Fc receptor, a critical binding agent for monoclonal neutralization. Studies describe that the two mutations result in an extended half-life of roughly 50 days and enhanced drug distribution to the respiratory system.

Entrez Symbol:

S

Uniprot Name:

Spike glycoprotein

Uniprot ID:

P0DTC2

Data PDF:

CPC538

Purity:

> 95% by reducing and non-reducing SDS-PAGE

Specificity:

Recombinant SARS-CoV-2 Spike Glycoprotein

Host Species:

Human

Immunogen:

Derived from antibody isolated in 2003 from an individual's memory B cells who had recovered from a SARS-1 coronavirus infection.

Isotype:

IgG

Clone:

VIR-7831 / GSK4182136 (Sotrovimab)

Formulation:

Sterile-filtered PBS, pH 7.5 preservative free.

Purification:

Protein A affinity chromatography

Application:

ELISA, FS , Neutralizing , WB

Storage/Stability:

Stable at 2-8°C for 1 week or for up to 1 year at -20°C to -80°C. It is recommended to prepare single-use aliquots of undiluted product and store -20°C to -80°C.